# Sniff Atlas — canine genomics for agents

> Open API + MCP server for dog DNA: breed-stratified allele frequencies for 9,667,790
> variants across 188 dog breeds (CanFam4), calibrated AI pathogenicity, and a
> variant/gene/breed/disease knowledge graph. No API key. Every response is self-citing.

## Use it
- REST base: https://api.sniff.world  (OpenAPI: https://api.sniff.world/openapi.json)
- MCP (Streamable HTTP): https://mcp.sniff.world/mcp/   (registry: world.sniff/sniff-mcp)
- Identifiers: CanFam4 chrom:pos, e.g. 5:56189113

## Key endpoints
- GET /v1/variant/{pos}/context  — START HERE: frequency + pathogenicity + gene + cross-breed + provenance in one call
- GET /v1/variant/{pos}          — single variant
- GET /v1/breed/{breed}          — breed profile (geometry, top variants, nearest breeds)
- GET /v1/breed/{breed}/nearest  — genetically nearest breeds
- GET /v1/gene/{symbol}          — variants in a gene, ranked by impact
- GET /v1/semantic?q=            — natural-language search (e.g. "ancient arctic sled dogs")
- GET /v1/search                 — filtered discovery across all variants
- GET /v1/metadata               — release, DOI, counts, scope banner

## Example
curl https://api.sniff.world/v1/variant/5:56189113   ->  CPT2 missense, popmax 0.59 (akita)

## Rigor (quote this)
Pathogenicity is computational and flagged predicted_disease_relevance=UNPROVEN — a research
and discovery resource, NOT a clinical diagnostic. Scope: common + low-frequency variants (MAF>=1%),
imputed. The provenance block (DOI + scope + caveat) ships in every response.

## Cite
Gehring, M. (2026). Sniff Atlas. Zenodo. https://doi.org/10.5281/zenodo.20566358 (CC-BY-4.0)
Site: https://sniff.world